Alternative roles for metal ions in enzyme catalysis and the implications for ribozyme chemistry

Article Abstract:

Divalent metal ion plays an essential role in the chemical mechanism of ribozyme catalysis through several pathways like direct coordination of divalent ions to functional groups in the transition state for stabilization of transition-state geometry and charge neutralization. However, it is revealed that the ability of monovalent ions and of the potassium ion is considered to directly support catalytic function.

Electrostatics, Catalytic RNA, Metal ions

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Recent developments in the application of oxazoline-containing ligands in asymmetric catalysis

Article Abstract:

The report on recent development in the design of oxazoline-based ligands for asymmetric catalysis is discussed. The broad utility of this class of ligands in catalytic asymmetric synthesis is demonstrated by the high enantiocontrol induced in a diverse array of metal-catalyzed transformations ranging from oxidations and reductions to cycloadditions and carbon-carbon bond-forming reactions.

Ligands (Biochemistry), Chemical bonds

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The Sonogashira reaction: A booming methodology in synthetic organic chemistry

Article Abstract:

The developments in the Sonogashira cross-coupling reaction and applications of this methodology since 2003 are described. Palladium ligands and palladium containing species were largely employed in Sonogashira coupling but at present more active catalysts are used and this has allowed coupling procedures.

Mechanical properties, Palladium catalysts, Spin coupling

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