Applications of sulfoxides to asymmetric synthesis of biologically active compounds

Article Abstract:

Sulfoxides induce the formation of chirals and can be used to prepare biologically active compounds such as carbinols. The substitutes present at the alpha and beta carbon atom determine the structure of the sulfoxide while those on the sulfur atom form a stereogenic center. This stereogenic center controls the stereochemistry of the compounds being formed. The conformation of the compound formed changes in the presence of metal atoms. The formation of optically active secondary methylcarbinols is given.

Sulfur compounds

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Acyclic stereocontrol induced by allylic alkoxy groups. Synthetic applications of stereoselective dihydroxylation in natural product synthesis

Article Abstract:

The allylic alkoxy group can be used to achieve acyclic stereocontrol. These allelic alcohols exhibit stereochemical control during the formation of compounds such as hikizimycin, fungal poisons, diols and iodohydrin. The alcohols are used in the addition of a nitrile oxide to allelic alcohols and ethers and Diels-Alder reactions. Olefines containing one substituent become highly stereoselective on dihydroxylation. However the diastereofacial selectivity of osmylated allylic amino compounds is poor.

Alcohols

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Stereochemical control in organic synthesis using silicon-containing compounds

Article Abstract:

Silicon-containing compounds were employed for organic synthesis stereochemical regulation and stereoselective reaction. Stereochemistry control is achieved by silicon by combining two molecules and stemming transition structure conformation. Chiral information can also be transmitted to organic frameworks by a chiral silyl group. There are various ways of using silyl groups in organic synthesis for stereochemistry regulation.

Silicon compounds

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