CC-1065 and the duocarmycins: synthetic studies

Article Abstract:

Synthetic approaches to the natural duocarmycins and CC-1065 products have been developed through a wide range of studies, with the nature of DNA alkylation reaction determined in part by the agents identified from studies of analogs containing deep structural changes. These studies also identify relationships between biological activity, chemical reactivity and structure, the DNA alkylation reaction catalysis source, and the source of DNA alkylation selectivity. The efficacy and potency of the analogs could be better than those of the natural products. Additional analogs could still potentially be developed.

Organic compounds, Organic compound synthesis, Synthetic products

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Structural aspects of stereodifferentiation in the solid state

Article Abstract:

The structures of cyclodextrin complexes in the crystalline state are primarily determined by the intrinsic properties of the macrocycle and crystal packing. The cyclodextrin cavity is very much hydrophobic and has a positive charge. Hence, an anion is easily inserted into the cavity when it is complexed with ionic guests. X-ray structures show that monosubstitution of cyclodextrins have nothing to do with their macrocylic shape. However, methylation of the O-2, O-3 or O-6 hydroxyl groups of the cyclodextrin alters the physical characteristics of the cavity.

Analysis, Cyclic compounds, Solid state chemistry, Cyclodextrins

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