Degrees of difficulty of water-consuming reactions in the absence of enzymes

Article Abstract:

Two practical benefits yield out of experiments establishing reaction rate constants in water in the absence of catalyst, as benchmarks for comparison with the rate constants of enzyme reactions. The greater the rate enhancement an enzyme produces, the greater is its expected sensitivity to inhibition by an ideal transition state analogue and the rate enhancement produced by an enzyme makes it possible to estimate the affinity and to perform a detailed thermodynamic analysis of the shortcomings of existing inhibitors.

Thermodynamics, Water consumption, Transition state (Chemistry)

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Single molecule studies of enzyme mechanisms

Article Abstract:

A demonstration is provided that single molecule methodology is a useful tool to probe enzyme mechanisms. A concentration is made on the use of fluorescence microscopy for studying enzyme reactions where the most important aspect of the experimental method in fluorescence microscopy is to focus the light in a very small volume to reduce the background fluorescence.

Usage, Fluorescence microscopy

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Computational and theoretical methods to explore the relation between enzyme dynamics and catalysis

Article Abstract:

Fast subpicosecond enzyme motions are highlighted and techniques used in studying the dynamics of enzymatic systems are developed. Computational and theoretical methods are used for exploring the relation between enzyme dynamics and catalysis.

Chemical reactions

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