Hyaluronan: preparation, structure, properties, and applications

Article Abstract:

The chemical and the physicochemical characteristics of hyaluronan (HA) were reviewed to relate the significance of HA in pharmaceutical research and applications. HA is a linear, unbranched polymer considered as a member of the polysaccharide family having a high molecular weight. The degradation methods for HA were through ultrasonic treatment, pH-dependent and thermal degradation, free radical depolymerization and catalytic enzymes. The physicochemical features of HA made the chemical an important entity in the field of ophthalmology and in drug delivery systems.

Drug delivery systems, Biopolymers, Hyaluronic acid, Polysaccharides, Ophthalmology

---

Target-related applications of first principles quantum chemical methods in drug design

Article Abstract:

Applications of quantum mechanics (QM) in drug design are reviewed focusing exclusively on target-based studies carried out on pharmacologically relevant protein systems. It is concluded that QM methods combined with either free energy perturbation or umbrella sampling allow accounting for environmental effects, to accurately estimate the entropy and to calculate a realistic free energy profile associated with a certain biological reaction.

Italy, Usage, Quantum theory, Quantum mechanics, Pharmaceutical research

---

Gadolinium(III) chelates as MRI contrast agents: structure, dynamics, and applications

Article Abstract:

The structure, physical properties, macromolecular conjugates, and applications of gadolinium are described. Gadolinium is used as a contrast agent in MRI imaging because it has magnetic properties.

Magnetic resonance imaging, Inorganic compounds, Contrast media, Contrast media (Chemicals), Gadolinium

Similar abstracts:

• Abstracts: Hyaluronidases: Their genomics, structures, and mechanisms of action. Spectroscopic characterization of distortion in enzyme complexes
• Abstracts: Ag(I) N-heterocyclic carbene complexes: Synthesis, structure, and application. Total synthesis of natural 8- and 9-membered lactones: Recent advancements in medium-sized ring formation
• Abstracts: Implicit solvation models: equilibria, structure, spectra, and dynamics. Multidimensional tunneling, recrossing and the transmission coefficient for enzymatic reactions
• Abstracts: Isokinetic relationship, isoequilibrium relationship, and enthalpy-entropy compensation. Description of electron deliocalization via the analysis of molecular fields
• Abstracts: Calculating log P(sub oct) from structures. Transesterification. Adenosine receptor antagonists: translating medicinal chemistry and pharmacology into clinical utility

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.