Introduction: DNA damage and repair

Article Abstract:

The chemical modification of only a single nucleotide in the human genome can affect an individual's fitness, although the chemical bonds in DNA are exceptionally stable generally. The knowledge of the various types of DNA repair pathways and the study of the roles of a broad family of mechanically distinct DNA polymerases help evolve elaborate mechanisms for repairing damaged DNA, which restore the original chemical information encoded in the genome.

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DNA mismatch repair: Functions and mechanisms

Article Abstract:

Mismatches within the DNA helix, caused by natural consequence of genetic recombination, replication errors and base pair anomalies resulting from DNA damage, are repaired by the DNA mismatch repair system. The mismatch repair system is involved in the cellular response to lesions caused by chemical carcinogens and ultraviolet irradiation and significantly reduces the recovery of genetic alterations that occur at A-T base pairs of DNA.

Methods, DNA synthesis

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A mechanistic perspective on the chemistry of DNA repair glycosylases

Article Abstract:

The authors review the publications on DNA base excision repair. The topics of interest include the pathway for finding a damaged bases in genomic DNA, the mechanism of DNA base flipping and enzymatic strategies for cleaving the glycosidic bond.

Analysis, Genetic aspects, Glycosylation, Chemical research, Chemical bonds, Properties

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