Molecular mechanisms and mammalian global genome nucleotide excision repair

Article Abstract:

Two pathways of nucleotide excision repair (NER), global genome NER (GG-NER) to detect and remove lesions throughout the genome and transcription coupled NER (TC-NER) to ensure faster repair of lesions located on the transcribed strand of actively transcribed genes are studied. It is observed that the NER proteins in the GG-NER pathway in mammalian cells, which displays a sequential assembly mechanism, move freely through the nuclei of nonradiated cells and are transiently immobilized to perform repair upon UV irradiation.

Genomes

---

Lagging strand replication proteins in genome stability and DNA repair

Article Abstract:

Lagging strand replication proteins reveal multiple mechanisms and pathways for the replication of repeat sequences to avoid mutation and the rescue of a stalled replication fork, which are critical to genome maintenance. These proteins are also involved in DNA damage repair pathways such as nucleotide excision repair and base excision repair, which employ mechanisms of end processing and ligation.

Analysis, DNA replication

---

Prokaryotic nucleotide excision repair: The UvrABC system

Article Abstract:

Nucleotide excision repair (NER) in prokaryotes is a DNA repair system, wherein insertion of short stretches of new DNA into repair patches takes place, along with dimer removal. The UvrABC system, comprising of uvrA, uvrB and uvrC genes responsible for NER, is a complex network that responds to stress placed on the cell.

Genetic aspects, Prokaryotes

Similar abstracts:

• Abstracts: Molecular mechanisms for the B-Z transition in the example of poly[d(G-C).d(G-C)] polymers. A critical review
• Abstracts: Measurement of OH and HO2 in the troposphere. Dynamical studies of the ozone isotope effect: A status report
• Abstracts: Introduction: DNA damage and repair. A mechanistic perspective on the chemistry of DNA repair glycosylases. DNA mismatch repair: Functions and mechanisms

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.