Molecular modelling studies of a nerve growth factor receptor

Article Abstract:

A precise atom-level model of the high-affinity nerve growth factor (NGF) receptor has been developed. A geometry for the receptor binding site for NGF was proposed based on computer simulations. Variable basis annealing calculations which were Monte Carlo simulated were used to establish the structures of the complexes for four entirely active NGF analogues with the second leucine-rich motif of trkA, said to be a binding site for NGF. The three-dimensional structures of the binding domains of the totally active NGF analogues are organized in advance for stereochemical fit with the second leucine-rich motif of trkA.

Usage, Physiological aspects, Alzheimer's disease, Binding sites (Biochemistry), Active sites (Biochemistry), Leucine, Growth factor receptors, Computer simulation, Chemistry, Physical and theoretical, Physical chemistry, Stereochemistry, Nerve growth factor, Neurotrophic functions, Neurotrophins

---

Alumina-assisted reduction of carbonyl compounds with sodium borohydride in hexane

Article Abstract:

Alumina-assisted reduction of carbonyl compounds with sodium borohydride in hexane has been studied. The sodium borohydride-based biphasic system can be used successfully for reduction of unsaturated substrates and of steroidal and very hindered ketones. A broad range of compounds were smoothly reduced with a combination of common, inexpensive reagents in hexane to give corresponding alcohols selectively and with high yields. Conditions were mild and neutral.

Japan, Analysis, Oxidation-reduction reaction, Oxidation-reduction reactions, Aluminum oxide, Alcohols, Carbonyl compounds, Borane

---

Similar abstracts:

• Abstracts: NMR studies of Cathode materials for lithium-ion rechargeable batteries. Lithium batteries and cathode materials
• Abstracts: Molecular mechanisms underlying nonribosomal peptide synthesis: Approach to new antibiotics. Glycopeptide and lipoglycopeptide antibiotics
• Abstracts: Crossed-beam studies of neutral reactions: state-specific differential cross sections. Aging of organic aerosol: Bridging the gap between laboratory and field studies
• Abstracts: Theoretical methods of potential use for studies of inorganic reaction mechanisms. Aromatic molecular-bowl hydrocarbons: Synthetic derivatives, their structures, and physical properties
• Abstracts: Vibrational spectroscopic studies of aqueous interfaces: Salts, acids, bases, and nanodrops. First-principles approaches to the structure and reactivity of atmospherically relevant aqueous interfaces

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.