Molecular mechanisms underlying nonribosomal peptide synthesis: Approach to new antibiotics

Article Abstract:

The global overview of the understanding of natural nonribosomal peptide synthesis (NRPS) and of progress in genetically engineered and chemoenzymatic synthesis of nonribosomal peptide products is provided. NRPS are highly sophisticated natural nanomachines that were optimized for the biosynthesis of compounds that cannot be produced by the ribosomal machinery and were selected during evolution for diverse structures and for broad biological activities.

Peptide synthesis

---

Glycopeptide and lipoglycopeptide antibiotics

Article Abstract:

A study was conducted to explain how access to unnatural glycopeptides enabled to identify new targets of the glycopeptide class and activity differences observed for natural glycopeptides against different bacterial pathogens. Also, an analysis was made on the ways in which resistance to the glycopeptides will develop and the efforts to develop glycopeptides that can overcome resistance were summarized.

---

Thiopeptide antibiotics

Article Abstract:

The thiopeptide antibiotics are naturally occuring, sulfur-containing, highly modified, macrocyclic peptides, nearly all of which inhibit protein synthesis in bacteria. The mode of action of thiopeptides for inhibition of bacterial protein synthesis, their biosynthetic mechanisms, and the origin of resistance determinants are described.

Protein synthesis, Protein biosynthesis

Similar abstracts:

• Abstracts: Molecular mechanisms and mammalian global genome nucleotide excision repair. Prokaryotic nucleotide excision repair: The UvrABC system
• Abstracts: Molecular insights into aminoglycoside action and resistance. Femtosecond studies of solvation and intramolecular configurational dynamics of fluorophores in liquid solution
• Abstracts: New trends in the synthesis of pi-electron donors for molecular conductors and superconductors. Synthesis and reactivity of Ru-, Os-, Rh-, and Ir-halide-sulfoxide complexes
• Abstracts: Conducting organic radical cation salts with organic and organometallic anions. Organic conductors with unusual band fillings
• Abstracts: Chemistry and biology of Ramoplanin: A lipoglycodepsipeptide with potent antibiotic activity. Synthetic preparation of N-Methyl-alpha-amino acids

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.