Chemistry and biology of Ramoplanin: A lipoglycodepsipeptide with potent antibiotic activity

Article Abstract:

Ramoplanin is active against a wide range of Gram-positive organisms, including many different species of Staphylococcus, Enterococcus, and Bacillus and it displays no activity against Gramnegative bacteria. The understanding of the mechanism of action of ramoplanin and an introduction to the primary structure of ramoplanin, its spectrum of activity, and also its current clinical indications are presented.

Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Bacteriostats, Antibacterial agents, Ramoplanin (Medication)

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Synthetic preparation of N-Methyl-alpha-amino acids

Article Abstract:

N-methylamino acid (NMA) containing peptide natural products are isolated from a variety of sources, and their secondary metabolites are found to have clinical use in part to the physical and chemical properties. Studies on NMA containing peptides reveal that N-methyl amino acid residues increase proteolytic stability and membrane permeability.

Amino acids, Chemical properties

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Kinetics and mechanisms of formation and reactivity of non-heme iron oxygen intermediates

Article Abstract:

Dioxygen-binding and -activating biomolecules with non-heme iron centers include a unique glycopeptide antibiotic bleomycin and numerous proteins. A discussion is presented on the kinetics and mechanisms of dioxygen binding and activation with mono- and dinuclear non-heme iron complexes and related reactions.

Analysis, Chemical reaction, Rate of, Chemical kinetics, Bleomycin

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