Nickel-containing carbon monoxide dehydrogenase/acetyl-CoA synthase

Article Abstract:

A nickel-containing enzyme functions as both carbon monoxide dehydrogenase and acetyl-CoA synthase, to catalyze exchange reactions. These reactions are between CO and the carbonyl group of acetyl CoA, and between free CoA and the CoA group of acetyl-CoA. The reaction mechanism of acetyl-CoA synthase involves insertion reactions in adjacent groups in the coordination sphere and the occupation of a coordination site cis to the the newly formed acyl group by the incoming group. Mononuclear nickel complexes undergo intramolecular insertion to give thioesters and acyl complexes.

Dehydrogenases, Oxidoreductases, Nickel

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Tungstoenzymes

Article Abstract:

The aldehyde ferredoxin oxidoreductase type of enzymes found in hyperthermophilic archaea and acetogenic bacteria are the true tungstoenzymes because of their phylogenetically distinct nature. The enzyme contains a tungsten atom coordinated to four sulphur atoms from two molecules of the non-nucleotide form of the pterin cofactor. The hyperthermophiles require tungsten to catalyze certain conversions in very low potential reactions at extreme temperatures.

Microbial enzymes, Tungsten

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The mononuclear molybdenum enzymes

Article Abstract:

The mononuclear molybdenum enzymes fall under the class of oxotransferases and have a Mo=O unit in their active sites. These catalyze the oxidative hydroxylation of aldehydes and aromatic heterocycles, and oxygen-transfer reactions. The structure of these enzymes constitutes a pyran ring in addition to the pterin ring structure and dithiolene side chain.

Hydroxylation, Molybdenum

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