RNA polymerase encounters with DNA damage: Transcription-coupled repair or transcriptional mutagenesis?

Article Abstract:

The DNA damage stall RNA polymerase (RNAP), depending on sequence context, the conformation of the base when it is met by RNAP and the presence of DNA damage-binding proteins. Transcription-coupled repair (TCR) recognizes and removes the stalled RNAP, repairs and resets transcription allowing RNA synthesis recovery, while transcriptional mutagenesis (TM) leads to bypass of the lesions by RNAP and insertion of incorrect nucleotides, leading to generation of a mutant transcript.

RNA polymerases, Mutagenesis, Structure, Chemical properties

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Antitumor antibiotics: Bleomycin, enediynes, and mitomycin

Article Abstract:

The current level of understanding and emerging trends relevant to the DNA-damaging metabolite families of the bleomycins, 9- and 10-membered enediynes, and mitomycins are mainly focused. A comparison of resistance mechanisms within producing organisms to those predominant among tumor cells reveals remarkable potential for continued development of these essential anticancer agents.

Drug therapy, Dosage and administration, Antineoplastic antibiotics, Bleomycin (Medication)

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