Stereoselective approaches to bioactive carbohydrates and alkaloids - with a focus on recent syntheses drawing from the chiral pool

Article Abstract:

Approaches to biofunctional carbohydrates and hydroxlated alkaloids have changed in a number of laboratories. One approach is by stereoselective synthesis of biologically active carbohydrates and hydroxylated alkaloids with the use of chiral nonracemic compounds. This method uses precursors or templates of the chirals and is highly flexible. A number of compounds can be easily prepared. The syntheses of monosaccharides and their aminated derivatives, oligosaccharides containing a carbon-carbon bond in place of the glycosidic oxygen and monocyclic and bicyclic alkaloid derivatives which contain a nitrogen atom in the ring and behave like sugars are given.

Analysis, Usage, Stereochemistry, Enantiomers

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Design constraints in practical syntheses of complex molecules: current status, case studies with carbohydrates and alkaloids, and future perspectives

Article Abstract:

Chemists have developed various methods toward the creation of synthetic plans. One of these is the multigenerational approach to solving synthetic problems. This approach involves the use of new technologies to aid in the overall efficacy of execution of multistep synthesis. Central to this approach is recognition of the pattern that connects starting material to product. A flowchart representation of problem analysis used in this approach is provided. The application of this methodology to selected examples such as carbohydrates and alkaloids is also presented.

Methods, Chemistry, Organic, Organic chemistry

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The vinylogous adol reaction: a valuabe, yet understated carbon-carbon bond-forming maneuver

Article Abstract:

Vinylogous dienolates and their synthons have a rich adol chemistry. The vinylogous adol reaction gives access to many structurally diverse targets, but has been a neglected area of organic synthesis for a long time.

Vinyl polymers

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