Multidimensional separations-based shotgun proteomics

Article Abstract:

The development of multidimensional chromatography coupled to tandem mass spectrometry for shotgun proteomic analyses which are frequently performed to obtain information ranging from simple protein identification to more complex post-translational modification studies are reviewed.

Cations, Properties, Isoelectric focusing, Protein-protein interactions

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Accurate mass measurements in proteomics

Article Abstract:

The emergence of the new generation of high-resolution mass spectrometry techniques, which enhances the fidelity, and robustness of large-scale proteomics analysis with both bottom-up and top-down strategies are reviewed.

Proteins, Proteomics, Protein separation

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Protein complexes in the gas phase: technology for structural genomics and proteomics

Article Abstract:

The application of mass spectrometry (MS) to the upper levels of protein organization where noncovalent interactions are preserved and which represents a crucial part of modern genomics and proteomics are reviewed.

Protein binding, Dissociation, Dissociation reactions

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