Total syntheses of pumiliotoxin A and allopumiliotoxin alkaloids. Interplay of pharmacologically active natural products and new synthetic methods and strategies

Article Abstract:

Pumiliotoxin A and allopumiliotoxin alkaloids are classes of naturally occurring active compounds found in skin secretions of a wide variety of amphibians including the Panamanian and Ecuadorian poison frogs. Previous studies have shown that pumiliotoxin A has the (Z)-6-alkylideneindolizidine ring system while allopumiliotoxins, which are congeners of pumiliotoxin A, have a vicinal diol group in the indolizidine ring. This review focuses on recent progress in the synthesis of these two toxins. The discussion is limited to methodologies that allow the preparation of the toxins in meaningful scales.

Research, Methods, Toxins, Chemistry, Organic, Organic chemistry, Alkaloids

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Modern methods of monosaccharide synthesis from non-carbohydrate sources

Article Abstract:

The modern methods of monosaccharide syntheses without using sugar-derived materials as starting materials are summarized. A summary and a reference guide for the methods that use sugars as the starting materials are also given. The preparation of natural and unnatural oligomers of sugars have many applications in the fields of medicine and biodegradable polymers. The syntheses of tetroses, pentoses, hexoses, cyclitols, amino sugars, pseudo sugars, and azasugars are described.

Analysis, Sugars, Carbohydrates

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