Body weight, fat storage, and alcohol metabolism

Article Abstract:

The effect of moderate alcohol consumption with a normal diet on the energy expenditure of eight human subjects is studied using indirect calorimetry. Ethanol was found to increase energy expenditure after 24 hours because adenosine triphosphate (ATP), the energy currency of the cell is not regenerated from adenosine diphosphate (ADP) in alcohol metabolism. It also affects fat metabolism although carbohydrate and protein metabolism are unchanged. The carbohydrate sparing effect is for maintaining balance by glucose oxidation. Ethanol does not affect the intake of other food but the positive energy balance with its intake causes fat accumulation.

Analysis, Physiological aspects, Alcoholism, Energy metabolism, Ingestion, Alcohol in the body

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Chronic alcohol intake interferes with retinoid metabolism and signaling

Article Abstract:

Chronic and excessive alcohol consumption is associated with fibrosis, cellular proliferation, cirrhosis, and liver cancer. A characteristic of alcohol-related injury is impaired vitamin A nutritional status, which is useful to understanding the mechanistic basis of the actions of alcohol and vitamin A on hepatic cell proliferation. Recent studies have shown chronic alcohol consumption reduces hepatic retinoic acid concentrations and retinoid signaling and enhances expression of activator protein-1, possibly resulting in liver cell proliferative activation.

Drinking of alcoholic beverages, Drinking (Alcoholic beverages), Liver cancer, Retinoids

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Is in vivo nuclear magnetic resonance spectroscopy currently a quantitative method for whole-body carbohydrate metabolism?

Article Abstract:

Assessment determines that nuclear magnetic resonance spectroscopy shows limitations in quantifying in vivo whole-body carbohydrate metabolism. Limitations stem from difficulties associated with conversion of a spectroscopic signal into a reliable and interpretable biochemical concentration, and then into a flux rate.

United States, Statistical Data Included, Evaluation, Magnetic resonance imaging, Carbohydrate metabolism, Nuclear magnetic resonance, Nuclear spectroscopy

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