Changes in liver structure and function after short-term and long-term treatment of rates with dehydroepiandrosterone

Article Abstract:

Dehydroepiandrosterone (DHEA) is a steroid hormone intermediate during the conversion of cholesterol to male and female sex hormones. Although it is not associated with other physiological roles, DHEA can cause ultrastructural changes in rat liver. An investigation was conducted to define DHEA-induced changes in rat liver cells. The results showed that short-term treatment of liver cells with DHEA leads to increases in cellular hypertrophy, peroxisome formation and number of mitochondria. Prolonged treatment led to degeneration of mitochondria, which may be the results of peroxisome-released substances.

Mitochondria, Peroxisomes, Dehydroepiandrosterone

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Dietary lipid regulates the amount and functional state of UDP-glucuronosyltransferase in rat liver

Article Abstract:

A study was done on the effect of dietary lipid on the amount and functional state of UDP-glucuronosyltransferase in rat liver. UDP-glucuronosyltransferase detoxifies endogenous compounds and xenobiotics. It was shown that fat content of the diet of rats regulates the activity of the enzyme by altering its total amount and activity per molecule. The amount of UDP-glucuronosyltransferase decreases upon removal of fat in the diet but an increase in the activity per molecule of enzyme can be observed.

Evaluation, Low-fat diet, Low fat diet, Lipids, Microsomes

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