Hyperresponsiveness to dietary cholesterol in inbred rabbits is not associated with enhanced reduction in binding of beta-VLDL to liver membranes
Article Abstract:
Hepatic apolipoprotein (apo) B/E receptors mediate the clearance of serum beta-VLDL and LDL. An investigation was conducted to determine the active apo B/E receptor levels in cholesterol-hyperresponsive and -hyporesponsive rabbits and the effects of cholesterol consumption on receptor activity. The results showed that hyperresponsive rabbits fed without cholesterol had 20% less receptors compared to hyporesponsive rabbits. However, cholesterol-induced depression of receptors was less effective in hyper- than in hyporesponders, indicating that enhanced depression of apo B/E receptors after cholesterol feeding does not occur in hyperresponsive rabbits.
Publication Name: The Journal of Nutrition
Subject: Food/cooking/nutrition
ISSN: 0022-3166
Year: 1992
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Secretion of lipoprotein cholesterol by perfused livers from rabbits hypo- or hyperresponsive to dietary cholesterol: greater dietary cholesterol-induced secretion in hyperresonpsive rabbits
Article Abstract:
Studies were made to test the hypothesis that hyperresponsive rabbits gain more plasma cholesterol than hyporesponsive rabbits, at any given dietary cholesterol intake. The rabbits were given diets with various cholesterol contents. Liver perfusions of various cholesterol amounts were also made. The hypothesis proved valid. The hyperresponders evidently absorb cholesterol better, secreting more in the liver while showing sluggish bile excretion. Yet, both types absorb cholesterol in the liver at the same rates and show a similar corresponding rise in lipoprotein cholesterol.
Publication Name: The Journal of Nutrition
Subject: Food/cooking/nutrition
ISSN: 0022-3166
Year: 1992
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Inbred strains of rats have differential sensitivity to dietary phosphorus-induced nephrocalcinosis
Article Abstract:
A study was done on the sensitivity of inbred rats to dietary phosphorus-induced nephrocalcinosis using kidney calcium concentrations and histological kidney calcification scores. Results show that 86% of the strain variability in nephrocalcinosis can be attributed to genetic factors. Strain differences in the response to urinary phosphorus concentrations was likewise used to explain the variable strain responses to phosphorus-induced nephrocalcinosis.
Publication Name: The Journal of Nutrition
Subject: Food/cooking/nutrition
ISSN: 0022-3166
Year: 1992
User Contributions:
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