OxyR: a regulator of antioxidant genes

Article Abstract:

The control of nine out of the 30 proteins responsible for the resistance against harmful oxidants in Escherichia coli and Salmonella typhimurium is affected by a gene called oxyR. The production of these hydrogen peroxide-inducible proteins is controlled by the oxidation of the OxyR protein translated from the oxyR gene. OxyR proteins are activated by the presence of oxidants in the system after which it binds to the genes it regulates promoting transcription of mRNAs and production of antioxidating proteins.

Research, Genetic regulation, Cellular control mechanisms, Cell regulation

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Copper as a cofactor and regulator of copper,zinc superoxide dismutase

Article Abstract:

The regulation of the activity antioxidant enzyme copper,zinc superoxide dismutase (CuZnSOD) seems to be dependent on copper alone. Deficiency in this metal is known to impair the function of CuZnSOD. The transport of copper into the enzyme through ceruloplasmin and albumin is enhanced and controlled by vitamin C. The assessment of CuZnSOD activity levels in normal subjects can give a reasonable approximation of the individual's nutritional status with respect to copper.

Copper, Superoxide dismutase

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Regulation of antioxidant enzymes

Article Abstract:

Antioxidant enzymes protect the body from the deleterious effects of free radicals, such as active oxygen species, by rendering them inactive in biological systems and unreactive to biomolecules. These group of enzymes have an integral requirement for trace elements, such as selenium, manganese, iron, zinc and copper, to complete its antioxidating function. The importance of these dietary minerals in the nutrition of higher and lower animals cannot be undervalued.

Free radicals (Chemistry), Free radicals

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