Patterns of age-related immunologic changes

Article Abstract:

Immunologic changes most often observed across species which exhibit decline with age are thymic tissue mass, antibody response, delayed-type hypersensitivity reaction, T cell proliferative response to polyclonal mitogen stimulation and the ratio of T cell subsets to naive cell surface markers. Four immunological changes which show an increase with age are variability in immune responses between individuals, production of autoantibodies and monoclonal immunoglobulins and the ratio of T cell subsets with memory membrane markers. The differences in findings may be attributed to such variables as age, health status, genetics, tissue selection and antigen dose.

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Immune senescence: deficiency or dysregulation

Article Abstract:

Immune defects associated with aging have increasingly been found to be more closely linked to immune dysregulation than to immune deficiency. A study on immune senescence, for example, revealed that a majority of individuals 65 years old and above appeared to have dysregulated immune system, as evidenced by the presence of serum antibodies. Another study revealed an age-associated loss of major histocompatibility complex-restricted T cell activity in humans. These results indicate that re-regulation of the elements that have dysregulated the immune system must be the focus in enhancing its adaptive function.

Aged, Elderly

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Cellular and biochemical changes in the aging mouse immune system

Article Abstract:

Immunogerontologists continue to grapple with the fact that as humans and animals age, the immune system produces fewer antibodies to specific antigens, fewer cytotoxic T cell effectors and exhibits reduced protection against possible infections and pathologic agents. The cellular and molecular explanations for the age-associated decline in immune responsiveness are also identified, including an age-related change in T cell subsets and a decrease in calcium signals and kinase specific signals.

Mice, Mice (Rodents)

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