Retinoids and carotenoids as inhibitors of carcinogenesis and inducers of cell-cell communication

Article Abstract:

The anticarcinogenic effect of retinoids and carotenoids is studied by applying weekly doses to mouse fibroblasts exposed to 3-methylcholanthrene in vitro to produce sarcoma. Suppression of the promotion stage of carcinomatous transformation is seen thus showing that retinol is chemopreventive and not chemotherapeutic. A similar effect is seen in carotenoids but these compounds have more variable tissue levels than retinoids. Retinoids and caroteinoids can prevent the progression of cancer by enhancing cell gap junctions and increasing synthesis of the junctional protein connexin, thus improving cell to cell communication which is needed for normal cell homeostasis.

Cancer, Chemotherapy, Junctional complexes (Epithelium)

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Methods for assessing the biological effects of specific plant components

Article Abstract:

Research to increase phytonutrients requires in vitro, animal, and human studies and establishing relevant biomarkers for chronic and fatal diseases. Data contributing to such study is developed through mechanistic, chemical, and genetic epidemiology.

Care and treatment, Chronic diseases, Epidemiological research, Cross sectional studies

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Retinoids, carotenoids, and human breast cancer cell cultures: a review of differential effects

Article Abstract:

Research has been conducted on the breast cancer. The effect of retinoids and carotenoids on breast cancer cells has been investigated.

United States, Statistical Data Included, Causes of, Breast cancer, Cell culture, Tissue culture

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