The influence of dietary fiber on proliferation of intestinal mucosal cells in miniature swine may not be mediated primarily by fermentation

Article Abstract:

High fiber diets are associated with a reduced tendency to develop colorectal cancer. It has been proposed that the effect of dietary fibers are mediated by various fermentation products, such as short-chain fatty acids (SCFA), which affect cellular proliferation and differentiation. This hypothesis was tested by measuring the proliferation of intestinal mucosal cells of miniature swine fed with various high fiber diets. The results showed that cell proliferation in the cecum and distal colon is correlated to the source and quantity of dietary fiber, but not to the quantities of water-soluble dietary fibers or SCFA.

Research, Colorectal cancer, Cell proliferation, Fiber in human nutrition, Dietary fiber, Rumen fermentation

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Rat colonic antioxidant status: interaction of dietary fats with 1,2-dimethylhydrazine challenge

Article Abstract:

The effect of dietary fat on colonic mucosal antioxidant mechanisms after treatment with 1,2 dimethylhydrazine (DMH) was investigated. The study specifically focused on whether the interaction of dietary fat with the oxidative challenge presented by DMH would cause cumulative damage to tissue antioxidant defenses. It was found that the kind and quantity of dietary fat modified antioxidant reponse but that all the diets gave the same degree of protection.

Dietary fat, Antioxidants, Antioxidants (Nutrients), Colon (Anatomy), Colon, Mucous membrane

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