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A 73-year-old man with severe facial pain, visual loss, decreased ocular motility, and an orbital mass

Article Abstract:

A 73-year-old man with increasing pain in the upper right side of his face and declining vision in his right eye was diagnosed with small lymphocytic lymphoma of the cavernous sinus. Six years prior to hospital admission, he had been diagnosed with chronic lymphocytic lymphoma (CLL). He also had very limited movement of the right eye, and a computed tomographic (CT) scan revealed a mass in the right eye extending into the cavernous sinus. After 13 days in the hospital, he became blind in his right eye. Cavernous sinus syndrome can have several causes, but his was most likely due to inflammation, a tumor or infection. Given the patient's history of CLL and diabetes, an infection was probable, but no infective agents were discovered. Further testing of tissue samples taken from the mass ruled out an inflammatory cause and confirmed the diagnosis of B-cell small-lymphocytic lymphoma. Upon autopsy, he was found to have leukemic meningitis with lymphoma in the cavernous sinus.

Author: Harris, Nancy L., Rubin, Peter A.D.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1993
Cases, Bone diseases, Lymphomas, Chronic lymphocytic leukemia

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A 16-year-old girl with fever, rash, and severe ocular disease

Article Abstract:

A young girl hospitalized with fever, rash, declining vision in one eye, weight loss, and drainage from the ear illustrates the presentation and diagnosis of systemic lupus erythematosus. The constellation of symptoms suggests an autoimmune disease or an infectious disease, such as herpes or HIV. Tests for antinuclear antibodies, HIV antibodies, antineutrophil cytoplasmic antibodies, and other serological values were performed. Following a diagnosis of lupus, with features of Wegener's granulomatosis, the patient received methylprednisolone and zidovudine, with considerable improvement in her symptoms.

Author: Lerner, Lisa H., Niles, John L., Schaller, Jane G.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1999
United States, Case studies, Systemic lupus erythematosus, Wegener's granulomatosis

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Ocular manifestations of HIV infection

Article Abstract:

The diagnosis and management of eye diseases caused by HIV infection are presented. The eyelids, conjunctiva and tear ducts are most often affected by herpes zoster, Kaposi's sarcoma, and molluscum contagiosum. The cornea, iris and anterior chamber are affected by viral infections, dry eyes and inflammation. The posterior chamber, retina and optic nerve head are affected by cytomegalovirus, varicella zoster, toxoplasma, and bacterial and fungal infections.

Author: Cunningham, Emmett T., Margolis, Todd P.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1998
Care and treatment, Causes of, Complications and side effects, HIV infection, HIV infections, Eye diseases, Ocular manifestations of general diseases, Eye manifestations

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