A comparison of nefazodone, the cognitive behavioral-analysis system of psychotherapy, and their combination for the treatment of chronic depression

Article Abstract:

Patients with depression who receive psychotherapy and also take the drug nefazodone do better than patients who only receive one of the treatments. This was the conclusion of researcher who randomly assigned 519 patients with depression to receive psychotherapy, nefazodone treatment, or both. Eight-five percent of the patients who received both treatments improved, compared to half the groups who received one treatment or the other.

Evaluation, Psychotherapy, Nefazodone

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Effectiveness of St John's Wort in Major Depression: A Randomized Controlled Trial

Article Abstract:

St. John's wort does not appear to be beneficial for people with major depression, according to a study of 200 patients. Some studies have shown a positive effect, but were not properly designed studies.

Health aspects, Alternative medicine, St. John's wort, Hypericum

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Bupropion-SR, sertraline, or venlafaxine-XR after failure of SSRIs for depression

Article Abstract:

The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial used an equipoise stratified, randomized design to evaluate the relative efficacy and tolerability of various antidepressant treatments for outpatients with nonpsychotic major depressive disorder who had a lack of remission or could not tolerate the selective serotonin-reuptake inhibitor (SSRI) citalopram. After unsuccessful treatment with a SSRI, approximately one in four patients had a remission of symptoms after switching to another antidepressant.

United States, Clinical trials, Drug therapy, Dosage and administration, Serotonin uptake inhibitors, Selective serotonin reuptake inhibitors, Sertraline, Venlafaxine, Bupropion, Citalopram

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