A dominant epitope of HIV-1 protease recognized by hamster monoclonal antibodies

Article Abstract:

Monoclonal antibodies against a protease produced by the human immunodeficiency virus type 1 (HIV-1) were able to recognize an enzyme component essential to the function of the protease. Proteases are enzymes that break down proteins. Armenian hamsters were inoculated with genetically-engineered HIV-1 protease. Three days later, their spleen cells were fused with a myeloma cell line to create monoclonal antibodies against the protease. Five of the antibodies produced by the hamsters reacted to a sequence of the protease close to the binding site for the substrate. If these antibodies can inhibit the protease, they may be useful in the development of therapeutic drugs which will inhibit the replication of the virus.

Analysis, Usage, Proteases, Monoclonal antibodies

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Clinical significance of HIV DNA in polymorphonuclear neutrophils from patients with HIV infection

Article Abstract:

DNA from the human immunodeficiency virus (HIV) was detected in the neutrophils of HIV-infected patients. Neutrophils are cells which play a part in immune responses. The breakdown of neutrophil activity is part of the process of infection with HIV. This decrease in functioning may play a role in the susceptibility of AIDS patients to diseases. Neutrophils were isolated from blood samples from 37 HIV-infected patients. HIV DNA was most often found in the neutrophils of patients who had symptoms of HIV infection. HIV DNA was found more often in patients with low blood levels of neutrophils. HIV DNA was also found more often in patients with Pneumocystis carinii pneumonia.

Health aspects, Physiological aspects, Pneumocystis carinii pneumonia, Neutrophils, Neutropenia

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