A once-daily lopinavir/ritonavir-based regimen provides noninferior antiviral activity compared with a twice-daily regimen

Article Abstract:

A pilot study evaluates the safety and noninferiority and explores the efficacy of administration of once-daily versus twice-daily lopinavir/ritonavir (LPV/r) in antiretroviral-naive HIV-1-infected subjects. During 48 weeks, a once-daily regimen of lopinavir/ritonavir + tenofovir disoproxil fumarate + emtricitabine appears to contain similar virologic and immunologic responses in antiretroviral-naive subjects as the same region with lopinavir/ritonavir administered twice daily.

Drug therapy, Anti-HIV agents

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The tablet formulation of lopinavir/ritonavir provides similar bioavailability to the soft-gelatin capsule formulation with less pharmacokinetic variability and diminished food effect

Article Abstract:

The bioavailability of tablet doses of lopinavir/ritonavir at 800/200 mg or 400/100 mg under different meal conditions are assessed and compared with equal doses of the soft-gelatin capsule (SGC) after a moderate-fat meal. The findings reveal that the diminished food effect and decreased variability of the tablet have resulted in more consistent lopinavir and ritonavir exposures, thereby minimizing the likelihood of extreme high or low values compared with the SGC.

Analysis, Bioavailability, Clinical report, Gelatin capsules

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Lopinavir/ritonavir as single-drug therapy for maintenance of HIV-1 viral suppression: 48-week results of a randomized, controlled, open-label, proof-of-concept pilot clinical trial (OK Study)

Article Abstract:

The maintenance with Iopinavir/ritonavir monotherapy vs. continuing Iopinavir/ritonavir and 2 nucleosides in Human Immunodeficiency Virus (HIV)-infected patients with suppresses HIV replication is evaluated. The results reveal that the failure of Iopinavir/ritronavir monotherapy are not associated with the development of primary resistance mutations in the protease gene and could be successfully reinduced adding back prior nucleosides.

Care and treatment, Genetic aspects, Antiretroviral agents, Iopidine (Medication)

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