A study of HIV RNA viral load in AIDS patients with bacterial pneumonia

Article Abstract:

Bacterial pneumonia may be linked with a steady rise in HIV RNA in AIDS patients. Serum samples from 13 patients with HIV who had antiretroviral therapy showed increased HIV RNA upon developing bacterial pneumonia. Before, during and after bacterial pneumonia, assays showed 60,000 copies per millimeter (ml), 245,000 copies per ml and 84,000 copies per ml, respectively. No significant change was seen in HIV RNA and in CD4 counts before and after pneumonia.

Pneumonia, RNA, Bacterial pneumonia

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T-cell homeostasis, competition, and drift: AIDS as HIV-accelerated senescence of the immune repertoire

Article Abstract:

A new hypothesis proposes that HIV hastens the aging of the immune system by creating holes in the T cell repertoire. Since HIV attacks CD4 T cells, it accelerates their turnover and eliminates many T cells that would destroy certain infectious organisms. The great diversity of T cells is then lost and the body can no longer fight off infections. AIDS could then be seen as the premature aging of the immune system.

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Primary proliferative responses to peptides of HIV Gag p24

Article Abstract:

Several peptide regions of the HIV gag p24 protein appear capable of stimulating T cell proliferation. Researchers exposed T cells from HIV-negative blood donors to dendritic cells containing 23 different peptides from the p24 protein. Eleven of the peptides induced significant T cell proliferation. Some of the peptides had not been previously identified. These peptides could be used in an AIDS vaccine.

Cell proliferation, Viral antigens

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