Absence of an environmental effect on the recurrence of facial-cleft defects

Article Abstract:

The risk of having a second child with a facial-cleft birth malformations may not be effected by where the mother lives, but may be reduced by her changing sexual partners. Researchers analyzed data from a Danish registry of people and a data base on facial-cleft birth defects that occurred in Denmark between 1936 and 1987. The researchers identified 4189 mothers who had at least one child with a cleft lip, cleft palate, or both. Changing residence did not effect the risk of having a second malformed child, but changing partners did. Among 1425 infants of mothers who neither moved nor changed partners, 3.4% had malformations; among 907 infants of mothers who moved but did not change partners, 3.2% had malformations. Among 2350 infants of mothers who did not change partners, 3.3% had malformations; however, among the 236 infants of mothers who changed partners 0.4% had malformations.

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What genome-wide association studies can do for medicine

Article Abstract:

Researchers' investigations into the environmental and inherited causes of common illnesses often result in the collection of vast amounts of data from people with common complex diseases well as the collection of biologic material such as deoxyribonucleic acid (DNA). These resources are an essential component for searching out genes relevant to disease through the use of the genome-wide association study, which in turn contributes to the understanding of diseases that have a genetic predisposition.

England, Methods, Analysis, Nucleotide sequence, Base sequence, Identification and classification, Genetic research, Human genome

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Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate

Article Abstract:

The study of 10 populations (comprising a total of 1968 families) with cleft lip or palate showed highly significant transmission disequilibrium for the V2741 variant of the IRF gene. The contribution of variants in single gene to cleft lip or palate is an important consideration in genetic counseling.

Genetic variation

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