The natural killer T-cell ligand alpha-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice

Article Abstract:

Research has been conducted on the diabetes development in a non-obese mice. Results demonstrate that alpha-galactosylceramide prevents diabetes in the wild-type but not I-like protein-deficient non-obese mice.

Diabetes, Diabetes mellitus, Autoimmune diseases, Ligands, Ligands (Chemistry)

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Activation of natural killer T cells by alpha-galactosylceramide treatment prevents the onset and recurrence of autoimmune type 1 diabetes

Article Abstract:

Research has been conducted on the type 1 diabetes in non-obese diabetic mice. Results indicate that alpha-galactosylceramide treatment protects female non-obese diabetic mice from type 1 diabetes and prolongs the pancreatic islets survival.

Canada, France, Research, Type 1 diabetes, Islands of Langerhans, Islets of Langerhans

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Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity

Article Abstract:

Research shows that the development of airway hyperreactivity requires the activation of pulmonary natural killer T cells, which produce interleukin-4 and interleukin-13. Data indicate that the pulmonary natural killer T cells may aid the lungs leading to type 2 T-helper responses, which mediate the development of airway hyperreactivity and asthma.

Biological Product (except Diagnostic) Manufacturing, Biological products exc. diagnostic, Interleukin, Asthma, Circulatory system, Interleukins, Cardiopulmonary system, Respiratory system, Killer cells, Respiratory organs

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