CD4 (super)+ T-cell-epitope mutant virus selected "in vivo"

Article Abstract:

Escape from CD4 (super)+ T lymphocytes may be a method viruses use to persist. Transgenic virus-specific CD4 (super)+ T cells have been seen to select for T-helper epitope mutant viruses that remain unrecognized.

Switzerland, Statistical Data Included, Genetic aspects, Viruses, Genomes, Mutation (Biology), Mutation, Antigenic determinants

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Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease

Article Abstract:

The circumstances under which CD8(super +)T cells specific for pancreatic beta-islet antigens induce disease in mice expressing lymphocytic choriomeningitis virus (LCMV) glycoprotein (GP) as a transgene under the control of the rat insulin promoter is discussed. Immunization with LCMV-GP derived peptide did not induce autoimmune diabetes despite large numbers of autoreactive cytotoxic cells.

United States, Autoimmune diseases, Viral meningitis

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Extralymphatic virus sanctuaries as a consequence of potent T-cell activation

Article Abstract:

The formation of extralymphatic sanctuary sites for viruses as a result of T-cell activation is examined. The ability of the T-cell activation coupled with antibody formation that eliminates specific viruses by making them easily detectable at their sanctuary sites is explained.

Immunoglobulins, Immunohistochemistry

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