Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross priming

Article Abstract:

The role of exosomes in the transfer of tumor antigens to dendritic cells in human in vitro model systems are examined. Topics include the implications exosomes have for T-cel cross priming as it relates to immunological interventions.

Statistical Data Included, Tumors, Immunological research, Immunologic research, Tumor antigens

---

A novel dendritic cell subset involved in tumor immunosurveillance

Article Abstract:

The identification of interferon-producing killer dendritic cells (IKDCs) as pivotal sensors and effectors of the innate antitumor immune response is discussed. Tumor outgrowth can be prevented by the adoptive transfer of IKDCs into tumor-bearing Rag2-II2rg mice.

Transforming growth factors, Immune response, Dendritic cells

---

Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

Article Abstract:

A previously unrecognized pathway is described in both mice and humans for the activation of tumor antigen-specific T-cell immunity that has involved secretion of the high-mobility-group box 1 (HMGB1) alarmin protein by dying tumor cells and the action of HMGB1 on Toll-like receptor 4 (TLR4) expressed by dendritic cells (DCs). The results have delineated a clinically relevant immunoadjuvant pathway triggered by tumor cell death.

Health aspects, Care and treatment, Cancer, Radiotherapy, Cancer cells, Chemotherapy, Clinical report

Similar abstracts:

• Abstracts: Receptor-dependent cell stress and amyloid accumulation in systematic amyloidosis. Amyloids: tombstones or triggers?
• Abstracts: The effectiveness and estimated costs of the access to baby and child dentistry program in Washington State. Effectiveness of local anesthesia in pediatric dental practice
• Abstracts: The effects of ibuprofen on the physiology and survival of patients with sepsis. Efficacy and safety of recombinant human activated protein C for severe sepsis
• Abstracts: Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration. Blood simple prion diagnostics

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.