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Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogenetic hematopoietic stem cell transplantation

Article Abstract:

A study was conducted infusing cultured mouse hematopoietic stem cells (HSCs), in vitro on OP9 mouse stromal cells expressing the Notch-1 ligand Delta-like-1 (OP9-DL1) together with T-cell-depleted mouse bone marrow or purified HSCs into lethally irradiated allogeneic recepients to determine their effect on T-cell reconstitution after transplantation. Results indicated that the adoptive transfer of OP9-DL1-derived T-cell precursors enhanced T-cell reconstitution, after transplantation, resulting in graft-versus-tumor (GVT) activity without graft-versus-host disease (GVHD).

Author: Zuniga-Pflucker, Juan Carlos, Heller, Glen, Pamer, Eric G., Zakrzewski, Johannes L., Kochman, Adam A., Sydney X. Lu, Terwey, Theis H., Theo D. Kim, Hubbard, Vanessa M., Muriglan, Stephanie J., Suh, David, Smith, Odette M., Grubin, Jeremy, Patel, Neel, Andrew Chow, Cabrera-Perez, Javier, Radhakrishnan, Radhika, Diab, Adi, Perales, Miguel-Angel, Rizzuto, Gabrielle, Menet, Ewa, Alpdogan, Onder, van den Brink, Marcel R.M.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
United States, Causes of, T cells

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Protecting the host naturally

Article Abstract:

Hematopoietic cell transplantation (HCT) is the only therapy for a range of hematologic malignancies but still, improvements in the procedure of HCT people suffer from graft-versus-host disease (GVHD). Hence, a new regimen is introduced that achieves engraftment with a remarkably low incidence of GVHD by reduced toxicity of such preparative regimens.

Author: Sykes, Megan, Spitzer, Thomas R.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
Care and treatment, Blood diseases, Hematologic diseases

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JAKing up immunosuppression

Article Abstract:

The effect of a new immunosuppressive agent on the cytoplasmic tyrosine kinase Janus kinase-3 (JAK-3), developed by Changelian et al., is analyzed. The probable potential toxicities and side effects are commented.

Author: Sykes, Megan
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
Immunosuppressive agents, Immunosuppression

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Subjects list: Research, Hematopoietic stem cells, Hematopoietic stem cell transplantation, Graft versus host reaction, Graft vs. host disease
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