Nonmyeloablative hematopoietic stem cell transplantation for systemic lupus erythematosus

Article Abstract:

The study is conducted to assess the safety of intense immunosuppression and autologous hematopoietic stem cell support in patients with severe and treatment-refractory systemic lupus erythematosus (SLE). It is found that in treatment-refractory SLE, autologous nonmyeloablative HSCT (haematopoietic stem cell transplantation) results in amelioration of disease activity, improvement in serologic markers and either stabilization or reversal of organ dysfunction.

Hematopoietic stem cells, Hematopoietic stem cell transplantation, Myeloblastic leukemia

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Novel lupus therapies show promise

Article Abstract:

Data from research using mouse models of systemic lupus erythematosus have provided evidence that understanding the role of epigenetics in a disease could lead to potential treatments. Mass spectrometry methods were used to examine the entire genome of individual mice for epigenetic changes and three previously unknown epigenetic changes were identified in samples from mice from a strain with a lupus-like disease.

Analytical Laboratory Instrument Manufacturing, Analytical instruments, Ion Mass Spectroscopy, Usage, Mass spectrometry

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Scientists probe child bipolar disorder

Article Abstract:

Scientists are adopting sophisticated imaging and other techniques for measuring brain activity in children diagnosed with bipolar disorder. The probe is aimed to better understand the pathophysiology of early onset bipolar disorder, and improve classification as well as treatment methods.

Diagnosis, Childhood mental disorders, Bipolar disorder, Child psychopathology, Brain mapping

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