Adverse effects of cyclooxygenase 2 inhibitors on renal and arrhythmia events: Meta-analysis of randomized trials

Article Abstract:

A class-wide meta-analysis of randomized trials of cyclooxygenase 2 (COX-2) inhibitors including rofecoxib, celecoxib, valdecoxib, parecoxib, etoricoxib and lumiracoxib is conducted in order to comprehensively quantify adverse risks and potential drug class effect for renal outcomes and arrhythmia events. Results reveal that rofecoxib increases risk of renal events and arrhythmia events, although a class effect is not evident, thus necessitating a cumulative and active surveillance system to monitor treatments.

Kidney diseases

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Cardiovascular risk and inhibition of cyclooxygenase: A systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2

Article Abstract:

A systematic review and meta-analysis of controlled observational studies is undertaken to compare the risks of serious cardiovascular events with individual nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase 2 inhibitors. The results confirm findings from randomized trials regarding the risk of cardiovascular events with rofecoxib, which suggest that celecoxib in commonly used doses, may not increase the risk.

Research and Development in the Physical, Engineering, and Life Sciences, Research and Testing Services, Heart & Cardiovascular R&D, Cardiovascular diseases, Cardiovascular research, Clinical report

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Sex differences of endogenous sex hormones and risk of type 2 diabetes: A systematic review and meta-analysis

Article Abstract:

A study was undertaken to understand the connection between the risk of type 2 diabetes and plasma levels of testosterone, sex hormone-binding globulin (SHBG) and estradiol. The conclusion reveals that endogenous levels of testosterone and SHBG each exhibit sex-dependent relations with risk of type 2 diabetes warranting further study of sex specific etiologies of type 2 diabetes and the complications connected with it.

Health aspects, Diabetics, Type 2 diabetes, Testosterone, Hormones, Sex, Sex hormones

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