Adverse events following pertussis and rubella vaccines: summary of a report of the Institute of Medicine
Article Abstract:
There appears to be a relation between immunization with DPT (diphtheria-pertussis-tetanus) vaccine and anaphylaxis or protracted crying in children who receive the vaccine. The rubella vaccine seems to be associated with acute and chronic arthritis in women who receive it. The National Academy of Sciences' Institute of Medicine (IOM) reviewed all published reports of possible side effects of DPT and rubella vaccines and found the evidence was most strong for these. IOM estimates 0.1% to 6% of children receiving DPT vaccine experience inconsolable crying. The institute estimates the rate of anaphylaxis to be two cases per 100,000 DPT injections. Among women who receive rubella vaccine, 13% to 15% develop acute arthritis, according to the IOM. Complete data on these associations can be found in the IOM report, Adverse Effects of Pertussis and Rubella Vaccines.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1992
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Chronic arthropathy after rubella vaccination in women: false alarm?
Article Abstract:
There is substantial evidence that the rubella vaccine does not cause chronic joint disease. Rubella vaccine was introduced in 1969 and since its use, the incidence of rubella, also called German measles, has dropped from an estimated 12.5 million cases in 1964 to only 128 cases in 1995. While rubella is generally mild in children, if a pregnant woman contracts rubella, it could damage the fetus. However, most countries routinely vaccinate all infants against rubella. The vaccine may cause symptoms of joint disease, but they are usually transitory and do not lead to permanent disability.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1997
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Risk of chronic arthropathy among women after rubella vaccination
Article Abstract:
There does not appear to be any link between rubella vaccination and joint disease. Researchers evaluated the health records of 4,884 women in a large HMO who were tested for rubella during pregnancy. A total of 971 were subsequently vaccinated and their risk of joint disease was compared to that in 3,345 unvaccinated women. Overall, 34 women developed some kind of joint disease within one year, 9 of whom had been vaccinated. Six of the vaccinated women developed symptoms within 6 weeks of vaccination. In most of the women, the symptoms lasted 6 weeks or less.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1997
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