Age and the cardiovascular system

Article Abstract:

Age-related changes in the cardiovascular system should be considered in diagnosing and treating heart disease in the elderly. These changes may exacerbate existing conditions such as coronary heart disease or be mistaken for disease. With age, there are physical changes in the heart, arteries and veins, the heart's output, heart beat, and blood pressure regulation. Normal body processes such as eating, changing position, urinating and defecating result in blood pressure drops not seen in younger people. Exercise places greater stress on the heart. However, aged heart patients often experience symptoms such as confusion, weakness and sleepiness in addition to the heart disease symptoms seen in younger patients. Heart disease is still the number one killer of people over 65, due largely to disease and not age. It is important to distinguish between age and disease-related effects in choosing the best treatment for elderly patients.

Aging, Aged, Elderly, Diseases, Cardiovascular system, Circulatory system

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Learning the value of drugs-is rofecoxib a regulatory success story?

Article Abstract:

Controversy over revelations concerning the adverse cardiovascular effects of selective cyclooxygenase-2 (COX-2) inhibitors has generally framed as a regulatory failure, in which the Food and Drug Administration (FDA) has failed in its mission to protect the public from unsafe products. Drugs are information-rich chemicals that in some respects resemble other information products more than they do other chemicals.

United Kingdom, Complications and side effects, Risk factors, COX-2 inhibitors, Rofecoxib

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A randomized comparison of radial-artery and saphenous-vein coronary bypass grafts

Article Abstract:

The left internal thoracic artery was used to bypass the anterior circulation in 561 patients, and the radial-artery graft was randomly assigned to bypass the major vessel. It was found that radial-artery grafts are associated with a lower rate of graft occlusion at one year than are saphenous-vein grafts.

Science & research, Research, Coronary artery bypass

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