Allogeneic bone marrow transplantation for chronic myeloid leukemia using sibling and volunteer unrelated donors: a comparison of complications in the first 2 years

Article Abstract:

Bone marrow transplantation from unrelated donors may be an effective treatment for patients with chronic myeloid leukemia without an HLA-identical sibling donor. An HLA-identical sibling has HLA antigens on the surface of their body tissues that are identical to those of the patient. Among 103 patients with chronic myeloid leukemia who had a bone marrow transplant, 46 had a unrelated donor and 57 had an HLA-identical sibling donor. There no significant difference in overall and disease-free survival among the two groups of patients. The incidence of severe viral infections was higher for patients with an unrelated donor. Patients with a unrelated donor also had a higher incidence of chronic graft-versus-host disease (GVHD) but not of acute GVHD.

Myeloid leukemia, Myelocytic leukemia

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Unrelated donor bone marrow transplantation for chronic myelogenous leukemia: a decision analysis

Article Abstract:

Patients with chronic myelogenous leukemia (CML) may benefit from bone marrow transplantation from an unrelated donor early in the disease cycle. Data from 778 patients with CML given unrelated bone marrow transplantations were used to construct a statistical model for evaluating life expectancy after early, late, or no transplantation during the disease cycle. Transplantation within the first year of CML identification could extend the life expectancy of a hypothetical 35-year-old patient by 5.3 years as compared to a matched patient with no transplantation.

Health aspects, Chronic myeloid leukemia, Life expectancy

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Discrepancies Between Patient and Physician Estimates for the Success of Stem Cell Transplantation

Article Abstract:

Patients with advanced blood disease may not be aware that a stem cell transplant may not cure them, according to a survey of 458 patients and their doctors. Doctors must correct any mistaken impressions patients may have about this procedure.

Beliefs, opinions and attitudes, Patients, Hematopoietic stem cells, Hematopoietic stem cell transplantation, Blood diseases, Hematologic diseases

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