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Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors

Article Abstract:

A hypothesis that pre-ligand binding assembly domain (PLAD)-mediated blockade of tumor necrosis factor receptor (TNFR) assembly might inhibit TNF-alpha signaling and ameliorate TNF-induced disease in a receptor-specific fashion is presented. Results reveal that soluble versions of PLAD, especially those derived from P60, block the biochemical effects of TNF-alpha in vitro and potently inhibit arthritis in animal models.

Author: Guo-Min Deng, Lixin Zheng, Francis Ka-Ming Chan, Lenardo, Michael
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
Arthritis

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Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2--dependent mechanisms

Article Abstract:

The role of adiponectin in myocardial remodeling in response to acute injury is examined. Ischemia-reperfusion in adiponectin-deficient (APN-KO) mice resulted in increased myocardial infarct size, myocardial apoptosis and tumor necrosis factor (TNF)-alpha expression compared with wild-type mice.

Author: Sato, Kaori, Walsh, Kenneth, Pimentel, David R., Shibata, Rei, Ouchi, Noriyuki, Takemura, Yukihiro, Funahashi, Tohru, Kihara, Shinji, Ohashi, Koji
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
Reperfusion injury

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Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation

Article Abstract:

The angiopoietins Ang-1 and Ang-2 are identified as ligands of the receptor tyrosine kinase Tie-2. Ang-2 is an autocrine regulator of endothelial cell inflammatory responses and acts as a switch of vascular responsiveness.

Author: Thurston, Gavin, Vajkoczy, Peter, Fiedler, Ulrike, Reiss, Yvonne, Scharpfenecker, Marion, Grunow, Verena, Koidl, Stefanie, Gale, Nicholas W, Witzenrath, Martin, Rosseau, Simone, Suttorp, Norbert, Sobke, Astrid, Herrmann, Matthias, Preissner, Klaus T., Augustin, Hellmut G.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
Science & research, Research, Tyrosine, Glycocalyx

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Subjects list: Care and treatment, United States, Physiological aspects, Tumor necrosis factor, Tumour necrosis factor, Health aspects
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