A rapid MMP-8 bedside test for the detection of intra-amniotic inflammation identifies patients at risk for imminent preterm delivery

Article Abstract:

A study is conducted to determine whether the results of a rapid MMP-8 (matrix metalloproteinase-8) bedside test predict imminent preterm delivery. The MMP-8 rapid test can identify patients at risk for preterm delivery within 7 days and 14 days and a positive test result can identify patients with intra-amniotic infection/inflammation with a high sensitivity and specificity, thus providing clinicians with a fast and accurate identification of preterm delivery risk and assessment of amniotic inflammation.

United States, Health aspects, Diagnosis, Risk factors, Medical examination, Pregnant women, Premature labor, Amniotic fluid, Premature labour

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Human spontaneous labor without histologic chorioamnionitis is characterized by an acute inflammation gene expression signature

Article Abstract:

The different biological processes involved during normal spontaneous labor are identified with the use of an unbiased genome-wide approach, while the transcriptome in the chorioamniotic membranes and maternal blood are also analyzed. The results have shown that the labor induces gene expression changes consistent with localized inflammation, despite the absence of histologically detectable inflammation.

Analysis, Genetic aspects, Gene expression, Chorioamnionitis, Disease/Disorder overview

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