An inexpensive, simple, and manual method of CD4 T-cell quantitation in HIV-infected individuals for use in developing countries

Article Abstract:

The manual cytosphere method using a hemocytometer with simple light microscopy is evaluated as a simple, reliable and cost-effective method, for the estimation of CD4+ T-lymphocyte counts in HIV-infected individuals, for use in the developing countries. The correlation of CD4+ T-lymphocytes as estimated by the new method with flow cytometry in patient populations at different stages of HIV infections is investigated.

Government domestic functions, Developing Countries, Health policy

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Highly active antiretroviral therapy restores CD4(super +) V beta T-cell repertoire in patients with primary acute HIV infection but not in treatment-naive HIV(super +) patients with severe chronic infection

Article Abstract:

The effects of highly active antiretroviral therapy on the reconstitution of the T-cell receptor repertoire in drug-naive HIV(super +) patients were analyzed. The results indicated that highly active antiretroviral therapy can restore the T-cell receptor repertoirein individuals whose immune system is not severely compromised by the infection.

United States, HIV infection, HIV infections, Dosage and administration

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Persistently biased T-cell receptor repertoires in HIV-1 infected combination antiretroviral therapy-treated patients despite sustained suppression of viral replication

Article Abstract:

Highly active antiretroviral therapy (HAART) reduces plasma viral load to copies/ml and increases CD4 T-cell number and function, in most HIV-1 infected patients. The patients starting with HAART at moderate levels of immunodeficiency have a fully suppressed viral load.

Observations

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