Anal cytology as a screening tool for anal squamous intraepithelial lesions

Article Abstract:

Anal cytology may be a useful technique in the diagnosis of anal squamous intraepithelial lesions (ASIL) in gay men. ASIL are a precursor of anal squamous cell cancer in the same way that cervical squamous intraepithelial lesions (CSIL) are precursors of cervical cancer in women. Researchers used a technique similar to a Pap smear to analyze anal cells taken from 407 HIV-positive and 251 HIV-negative gay men. A positive test identified 69% of the HIV-positive men subsequently shown to have ASIL on biopsy. It was less effective in identifying HIV-negative men with ASIL.

Abnormalities, Diagnosis, Gay men, Colorectal diseases, Intestinal diseases, Anus, Anorectal disorders

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DNA copy number alterations in HIV-positive and HIV-negative patients with diffuse large-cell lymphomas

Article Abstract:

Diffuse large-cell lymphoma in HIV patients has fewer DNA copy number changes than diffuse large-cell lymphoma in HIV-negative patients. Since changes in DNA copy number are one cause of this type of cancer, there must be other factors that cause the cancer in HIV patients.

Causes of, Lymphomas, Ploidy

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Longitudinal study of anti-Candida albicans mucosal immunity against aspartic proteinases in HIV-infected patients

Article Abstract:

Many HIV patients produce antibodies in their saliva against enzymes produced by Candida albicans. Unfortunately, the antibodies are not completely effective in preventing Candida infection of the oral mucosa, a condition commonly known as thrush.

Research, Physiological aspects, Candida albicans, Oral mucosa, Thrush (Mouth disease), Oral candidiasis

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