A multicenter trial of two dexamethasone regimens in ventilator-dependent premature infants

Article Abstract:

It does not appear to be beneficial to give dexamethasone to infants on ventilators any earlier than 4 weeks of age. Dexamethasone is believed to improve lung function and make it easier to take the infant off the ventilator. Researchers compared outcomes in 371 premature infants on a ventilator who were given dexamethasone at 2 weeks of age or at 4 weeks. The earlier administration of the drug did not significantly improve outcomes and increased the risk of hospital-acquired bacterial infections and hyperglycemia.

Care and treatment, Infants (Premature), Premature infants, Dosage and administration, Dexamethasone, Respiratory distress syndrome

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Outcome of extremely-low-birth-weight infants at highest risk: Gestational age less than or equal to 24 weeks, birth weight less than or equal to 750 g, and 1-minute Apgar less than or equal to 3

Article Abstract:

Neurodevelopment outcome in extremely low-birth weight (ELBW) infants is evaluated. It is important for perinatologists and neonatologists to be aware of the risk of mortality and morbidity in this high risk ELBW group.

United States, Science & research, Research, Causes of, Risk factors, Birth weight, Low, Low birth weight, Infants, Infant development, Gestational age

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