Antibody responses after immunization with killed oral cholera vaccines during the 1985 vaccine field trial in Bangladesh

Article Abstract:

Cholera is caused by infection with the bacteria Vibrio cholerae. It is characterized by watery diarrhea and may result in severe fluid loss from the body (dehydration). The disease can be passed from person to person and is more common in underdeveloped countries with poor sewage and water treatment systems. Two oral vaccines for cholera were developed and tested in children living in Bangladesh. One of the vaccines contained killed Vibrio cholerae (WC) and the other contained cholera toxin in addition to WC (WC/BS). (Cholera toxin is a poisonous substance produced by V. cholerae.) The goal of administering WC/BS was to provide protection against V. cholerae infection and the toxin. The study included 62,285 children (males from 2 to 15 years, and females 2 to over 15 years). The effectiveness of vaccination is measured by the production of antibodies. After the vaccines were given, blood samples were collected and tested for antibodies against V. cholerae and cholera toxin. Two weeks after vaccination, the amount of antibody against cholera toxin was two to four times greater in those who received the WC/BS vaccine, and the amount of antibody against V. cholera was one to two times greater in those given either vaccine. Seven months after vaccination the blood levels of antibodies against cholera toxin and V. cholera decreased. Despite this change, the vaccines provided protection from cholera infections for more than three years. (Consumer Summary produced by Reliance Medical Information, Inc.)

Evaluation, Prevention, Vibrio cholerae, Cholera, Cholera toxin, Oral vaccines

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Serum retinol and biochemical measures of iron status in adolescent schoolgirls in urban Bangladesh

Article Abstract:

Anaemic adolescent schoolgirls of urban Bangladesh have lower serum retinol content, packed cell volume, serum iron than those with normal haemoglobin levels. The anaemic girls also have a higher serum total iron binding capacity and lower transferrin saturation. This shows a significant relation between the retinol content and the serum iron and haemoglobin content. Higher vitamin A levels are associated with higher levels of iron in the blood.

Measurement, Iron in the body, Iron (Nutrient), Rosin-oil, Rosin oil

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Anaemia and iron deficiency among adolescent schoolgirls in peri-urban Bangladesh

Article Abstract:

A new study investigates iron-deficiency and anaemia among adolescent girls in peri-urban Bangladesh. It is shown that anaemia in this population is not totally explained by iron deficiency.

Research, Anemia, Causes of, Food and nutrition, Indigenous peoples, Diet therapy

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