Analysis of quinolone resistance mechanisms in a sparfloxin-resistant clinical isolate of Neisseria gonorrhoeae

Article Abstract:

The version of Neisseria gonorrhoeae which is resistant to quinolone type antibiotics, including sparfloxacin, has genetic mutations in the proteins known as GyrA and ParC. Noting the failure of sparfloxacin to treat a case of simple gonococcal urethritis, the resistance mechanisms were investigated. The two mutations mentioned above were found to be coupled with several more, with the ParC one most directly responsible for the dissipation of effects of sparfloxacin.

Analysis, Evaluation, Drug resistance in microorganisms, Microbial drug resistance, Quinolone antibacterial agents, Fluoroquinolones

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Prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, and HIV Infection Among Drug Users Attending an STD/HIV Prevention and Needle-Exchange Program in Quebec City, Canada

Article Abstract:

The authors determined the proportion of Chlamydia trachomatis, Neisseria gonorrhoeae, and HIV virus among drug users (both injecting and noninjecting) in the city of Quebec, Canada. The sexually transmitted diseases were found in moderate amounts, and HIV was found only in the injecting drug users, suggesting a needle-exchange program might be in the public health interest.

Health aspects, Statistics, HIV infection, HIV infections, Drug addicts, Drug abusers, Chlamydia trachomatis, Quebec, Quebec

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