Antitumor activity of thalidomide in refractory multiple myeloma

Article Abstract:

Thalidomide may be beneficial in some patients with a form of cancer called multiple myeloma. In a study of 84 multiple myeloma patients, most of whom had relapsed following chemotherapy, 32% benefited from thalidomide. Two patients had a complete remission, and several other patients had a partial response. In 78% of the patients, the benefit was apparent within two months. One-year survival rates were 58% in the group that responded to thalidomide and 22% in the group that did not. Of the 36 patients who died, 30 had not responded to the drug.

Health aspects, Thalidomide

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Bortezomib: Proteasome inhibition as an effective anticancer therapy

Article Abstract:

A study is conducted on bortezomib, a first-in-class proteasome inhibitor, which has been developed specifically for use as an antineoplastic agent. It is shown that the response rate of bortezmib was far better than the high-dose dexamethasone, in the phase III trial demonstration, and played an important role in the survival in patients with myeloma.

Product development, Science & research, Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Anticancer Drugs, Chemotherapeutic Drugs, Research, Antineoplastic agents, Antimitotic agents, Bortezomib

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A phase 2 study of bortezomib in relapsed, refractory myeloma

Article Abstract:

The drug Velcade may benefit some patients with multiple myeloma, according to a study of 193 patients who did not respond to other chemotherapy drugs. Thirty-five percent responded to the drug. The drug can suppress the immune system, and can cause fever and peripheral nerve disease.

Product information, Evaluation, Biotechnology industry, Biotechnology industries, Product/Service Evaluation, Millennium Pharmaceuticals Inc., MLNM, Velcade (Medication)

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