Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis

Article Abstract:

An investigation was carried out to study the direct consequences of vascular smooth muscle cell (VSMC) apoptosis by generating transgenic mice expressing the human diphtheria toxin receptor (hDTR) from a minimal Tagin promoter. Results indicated that VSMC apoptosis is silent in normal arteries, which have a large capacity to withstand cell loss, while in contrast, VSMC apoptosis alone is sufficient to induce features of plaque vulnerability in atherosclerosis.

Causes of, Physiological aspects, Apoptosis, Atherosclerotic plaque

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Connexin37 protects against atherosclerosis by regulating monocyte adhesion

Article Abstract:

An insight into the participation of connexin37 (CX37) in antherogenesis affected individuals was obtained on the basis of polymorphic gene association studies and protein expression analysis. Finding show that similar to other chronic inflammatory diseases, the development of antherosclerotic plaques represents a balance between the pro- and anti-inflammatory influences which shows that CX27 protects against excessive monocyte recruitment in antherosclerosis.

Care and treatment, Prevention, Genetic polymorphisms, Monocytes

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Fast track to the porphyrins

Article Abstract:

The way calorie restriction affects the production of porphyrin precursors that could trigger an acute attack is demonstrated. The production of excess porphyrin precursors in the liver causes attacks of the acute porphyrias, characterized by episodic neuropathic abdominal pain, peripheral neuropathies, potentially lethal respiratory paralysis and acute psychotic episodes.

Industrial Organic Chemicals, Cyclic Crude and Intermediate Manufacturing, Porphyrins, Risk factors

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