Association between fetal inherited thrombophilia and adverse pregnancy outcomes

Article Abstract:

Study is conducted to investigate the associations between fetal inherited thrombophilia and adverse pregnancy outcomes, including pregnancy-induced hypertensive disorders (PIHD), antepartum hemorrhage (APH), small-for-gestational age < 10th percentile (SGA), and preterm birth (PTB). Evidence suggests that fetal thrombophilia and adverse pregnancy outcomes are related, in particular to intrauterine growth restriction (IUGR) resulting in small-for-gestational age (SGA) infants.

Pregnancy, Complications of, Pregnancy complications, Disease/Disorder overview

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Etiology and pathogenesis of preeclampsia: current concepts

Article Abstract:

Four prominent hypotheses are under study to explain the causes and physiology of preeclampsia, a hypertensive complication of pregnancy. Inadequate blood supply to the placenta may cause placental tissue dysfunction. Very low density lipoproteins may have a toxic effect in some women. The developing embryo may induce an inappropriate immune response that alters the function of fetal membranes. Preeclampsia and the more severe eclampsia may be cause by a gene.

Physiological aspects, Eclampsia, Preeclampsia

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Associations between inherited thrombophilias, gestational age, and cerebral palsy

Article Abstract:

A large case-control study investigated the associations between inherited thrombophilic polymorphisms and cerebral palsy (CP). Methylenetetrahydrofolate reductase (MTHFR) C677T approximately doubles the risk of CP in preterm infants and a combination of homozygous MTHFR C677T and hererozygous prothrombin gene mutation increases the risk of quadriplegia 5-fold at all gestational ages.

Health aspects, Cerebral palsy, Birth defects, Infants (Premature), Premature infants, Gestational age

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