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Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX

Article Abstract:

A study to ascertain if the development of systemic lupus erythematosus (SLE) is influenced by the presence of certain genes is conducted. Results confirm that the hereditary genes play a role in the development as also reduced expression of BLK and increase depression of C8orf13 and variants in the ITGAM-ITGAX region.

Author: Manzi, Susan, Graham, Robert R., Gregersen, Peter K., Petri, Michelle, Rantapaa-Dahlqvist, Solbritt, Behrens, Timothy W., Chao Tian, Ballinger, Dennis G., Seldin, Michael F., Lee, Annette T., Hom, Geoffrey, Criswell, Lindsey A., Modrek, Barmak, Taylor, Kimberly E., Ortmann, Ward, Garnier, Sophie, Chung, Sharon A., Ferreira, Ricardo C., Pant, P.V. Krishna, Kosoy, Roman, Demirci, F. Yesim, Kamboh, Ilyas, Kao, Amy H., Gunnarsson, Iva, Bengtsson, Anders A., Ronnblom, Lars, Syvanen, Ann-Christine
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2008
United States, Development and progression, Gene expression, Systemic lupus erythematosus, Single nucleotide polymorphisms

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STAT4 and the risk of rheumatoid arthritis and systematic lupus erythematosus

Article Abstract:

The single-necleotide polymorphism was tested within the previously linked chromosome region for association with rheumatoid arthritis. Results showed that the halotype STAT4 was associated with increased risk of both rheumatoid arthritis and systematic lupus erythematosus.

Author: Klareskog, Lars, Graham, Robert R., Kastner, Daniel L., Gregersen, Peter K., Amos, Christopher I., Wentian Li, Carulli, John P., Behrens, Timothy W., de Bakker, Paul I.W., Plenge, Robert M., Seldin, Michael F., Alfredsson, Lars, Remmers, Elaine F., Lee, Annette T., Hom, Geoffrey, Le, Julie M., Hye-Soon Lee, Batliwalla, Franak, Masters, Seth L., Booty, Matthew G., Padyuko, Leonid, Wei V. Chen, Criswell, Lindsey A.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2007
Diagnosis, Lupus erythematosus

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TRAF1-C5 as a risk locus for rheumatoid arthritis- a genomewide study

Article Abstract:

The article discusses a study that helps in the identification of several genetic loci, including TRAF1 (encoding tumor necrosis factor-receptor associated factor 1) and C5 (encoding complement component 5) that increase the risk for rheumatoid arthritis considerably.

Author: Klareskog, Lars, Altshuler, David, Kastner, Daniel L., Amos, Christopher I., Wentian Li, Carulli, John P., Plenge, Robert M., Chao Tian, Seldin, Michael F., Padyukov, Leonid, Alfredsson, Lars, Remmers, Elaine F., Wei V. Chen, Criswell, Lindsey A., Seielstad, Mark, Lee, Annette, T., Bo Ding, Liew, Anthony, Khalili, Houman, Chandrasekaran, Alamelu, Davies, Leela R. L., Tan, Andrian K. S., Bonnard, Carine, Ong, Rick T. H., Thalamuthu, Anbupalam, Pettersson, Sven, Chunyu Liu, Gregerson, Peter K., Beckman, Evan M., Evan M.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2007
United Kingdom, Physiological aspects, Tumor necrosis factor, Quantitative trait loci, Tumour necrosis factor

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Subjects list: Research, Genetic aspects, Clinical report, Risk factors, Rheumatoid arthritis
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