Asthma, peripheral neuropathy, and eosinophilia in a 52-year-old man

Article Abstract:

A 52-year-old man was diagnosed with Churg-Strauss syndrome. Churg-Strauss syndrome is an allergic disorder that causes inflammation of blood vessels. The patient was admitted to the hospital with asthma, inflammation of the peripheral nerves, fever and high levels of white blood cells (WBC). The patient had a long history of sinus inflammation and nasal polyps, and he had developed bronchial asthma three years earlier. Four months before admission to the hospital, he experienced shortness of breath, chest pain and tingling in the hands. He had an intermittent low-grade fever, and suffered from nerve inflammation in different parts of the body. A chest X-ray revealed a nodule in the lower lobe of the left lung. A blood test found that his blood contained antibodies against the enzymes myeloperoxidase and proteinase 3. These results in combination with his other symptoms seemed to indicate that he had Churg-Strauss syndrome. A sural-nerve and muscle biopsy confirmed this diagnosis. The patient was treated with corticosteroids.

Churg-Strauss syndrome, Arteritis

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A 74-year-old woman with rapidly progressing renal failure after an upper respiratory tract infection

Article Abstract:

A 74-year-old woman was admitted to the hospital with an upper respiratory tract infection and progressive kidney failure and was diagnosed with microscopic polyarteritis. Polyarteritis is a form of systemic vasculitis characterized by the inflammation and cell death of blood vessels and associated organs. The woman had suffered a heart attack 14 months prior to admission and had a history of congestive heart failure and valvular diseases. X-rays revealed that her heart was enlarged but that her kidneys were normal in size. The normal size of her kidneys and the reduction in her urine volume suggested that her kidney failure was an acute form, not chronic. The multi-system involvement further suggested that her rapidly progressive kidney failure was due to either a bacterial infection or systemic vasculitis. She tested positive for antibodies to the enzyme myeloperoxidase, which confirmed the diagnosis of systemic vasculitis. At autopsy, vasculitis was also detected in her kidneys.

Periarteritis nodosa, Polyarteritis nodosa

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Rapidly progressive renal failure in a 35-year-old woman with systemic lupus erythematosus

Article Abstract:

A 35-year-old woman admitted to a hospital with progressive kidney failure was diagnosed with antiphospholipid antibody syndrome. She also had a history of systemic lupus erythematosus.

Antiphospholipid syndrome

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