Mucosal AIDS vaccine reduces disease and viral load in gut reservoir and blood after mucosal infection of macaques

Article Abstract:

Research has been conducted on HIV-1 mucosal transmission. Results indicate that mucosal cytoxic T lymphocytes can be induced via macaque intrarectal immunization with a synthetic-peptide vaccine which incorporates the LT(R192G) adjuvant and can protect rhesus macaques against mucosal infection with simian/human immunodeficiency virus.

Causes of, Physiological aspects, HIV (Viruses), HIV, Peptides, T cells

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Attenuated poxvirus-based simian immunodeficiency virus (SIV) vaccines given in infancy partially protect infant and juvenile macaques against repeated oral challenge with virulent SIV

Article Abstract:

In order to test pediatric vaccine candidates aimed at reducing HIV transmission through breast-feeding, an infant macaque model was developed. The results suggest that immunization of human infants with poxvirus-based HIV vaccine candidates may offer protection against early and late HIV infection through breastfeeding.

Science & research, Research, Risk factors, Breast feeding, Macaques, Simian immunodeficiency virus

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